Colony Stimulating Factor 2 Receptor Beta (CSF2Rb)

The CSF2RB gene encodes the high-affinity beta subunit of a receptor for interleukin-5 (IL5R; 147851), granulocyte-macrophage CSF (CSF2R). In the mouse, 2 distinct but related genes, AIC2A (Csf2rb2) and AIC2B (Csf2rb1), encode the beta subunit common to Csf2r, Il5r, and Il3r (Gorman et al., 1992). Hara and Miyajima (1992) stated that the mouse AIC2B gene encodes a common beta subunit for the mouse Gmcsf and Il5 receptors, whereas AIC2A encodes a low-affinity Il3-binding protein by itself. Hara and Miyajima (1992) found that AIC2A formed a high-affinity Il3-binding protein when coexpressed with a mouse protein homologous to the human alpha subunit. In addition, AIC2B formed a high-affinity Il3-binding protein when coexpressed with the alpha subunit.