Death Associated Protein 6 (DAP6)

DAXX ,a Death-Domain-Associated Protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. It has been associated heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation.DAXX is almost uniformally expressed throughout the body, except the testes and thymus have higher expression of the protein. At the level of the cell, DAXX is found as well in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as in the nucleus where it is interacting with some subnuclear structures. A lot of other interacting molecules are known, but not always, there is an understanding of the specific function and relevance of this interaction.