Anti-Ganglioside D3 Antibody (Anti-GD3)

Anti-ganglioside antibodies that react to self-gangliosides are found in autoimmune neuropathies. These antibodies were first found to react with cerebellar cells. These antibodies show highest association with certain forms of Guillain-Barré syndrome. Anti-GD3 antibodies (Anti-GD3)have been found in association with specific forms of Guillain-Barré syndrome. In vivo studies of isolated anti-GM1 and anti-GD3 antibodies indicate the antibodies can interfere with motor neuron function. Anti-GD1a antibodies were highly associated acute motor axonal neuropathy while high titers of anti-GM1 were more frequent indicating that GD1a possibly targets the axolemma and nodes of Ranvier most of the Ab+ patients had C. jejuni infections. Patients with Anti-GalNAc-GD1a antibodies were less common but had more severe disease (rapidly progressive, predominantly distal weakness).