Atlastin 1 (ATL1)

Atlastin 1 is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.The gene was found to have no homology to genes that cause other forms of hereditary spastic paraplegia. It does show significant homology to guanylate binding protein-1 (GBP1), a member of the dynamin family of large GTPases.