Cell Division Cycle Protein 14 (CDC14)

CDC14 is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.CDC14A interacted with interphase centrosomes, and this interaction was independent of microtubules and CDC14A phosphatase activity. The interaction required nuclear export, however, and disruption of the nuclear export signal (NES) led to CDC14A accumulation in nucleoli.