EF-Hand Calcium Binding Domain Protein 13 (EFCAB13)

C17orf57 Contains 6 EF-hand domains. The EF-hand motif contains approximately 40 residues and is involved in binding intracellular calcium. EF-hand domains are often found in single or multiple pairs, giving rise to various structural/functional variations in proteins containing EF-hand motifs. Proteins containing EF-hands can be grouped into two functional categories - regulatory or structural. Binding of calcium to regulatory EF hand domain-containing proteins induces a conformational change, which is transmitted to their target proteins, often catalyzing enzymatic reactions. In contrast, binding of calcium to structural EF-hand domain-containing proteins does not induce a significant conformational change. Structural EF-hand domains seem to play a role in buffering intracellular calcium levels.