Eukaryotic Translation Elongation Factor 1 Delta (EEF1d)

EEF1d encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined. The deduced 281-amino acid protein has a calculated molecular mass of 31 kD. It has an N-terminal leucine zipper domain and a C-terminal domain that is similar to that of EF1-beta and is predicted to show GDP/GTP exchange activity. EF1-delta also has a conserved serine phosphorylation site.