Eukaryotic Translation Initiation Factor 3D (EIF3D)

Eukaryotic translation initiation factor 3 subunit D is a protein encoded by the EIF3D gene.Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.The predicted 548-amino acid human p66 protein contains an RNA-binding domain within an arginine and lysine-rich N-terminal hydrophilic segment.