Formyl Peptide Receptor 2 (FPR2)

LXA4R, which was first identified based on sequence homology as the formyl peptide receptor like receptor (FPRL1). Lipoxin signaling through the LXA4R inhibits chemotaxis, transmigration, superoxide generation and NF-κB activation. Bao et al. (1992) identified 2 structural homologs of formyl peptide receptor (FPR1), FPRL1 (FPR2) and FPRL2 (FPR3). Since these 2 structural homologs did not recognize the ligand FMLP,Bao et al. (1992) referred to them as orphan receptors. Nonetheless, they probably function as chemotactic receptors.Prat et al. (2006) found that a Staphylococcus aureus protein, which they called FLIPr, bound to and impaired neutrophil responses to FPRL1 agonists in terms of calcium mobilization and directed migration.