Palladin (PALLD)

Palladin is a component of actin-containing microfilaments that control cell shape, adhesion, and contraction.The deduced 789-amino acid mouse protein contains an N-terminal serine- and proline-rich region and 3 C-terminal IgC2 domains. Palladin was expressed as a 90- to 92-kD doublet in fibroblasts.Northern and Western blot analysis of chick and mouse tissues detected multiple isoforms. Expression was ubiquitous in embryonic tissues and was downregulated in certain adult mouse tissues. Palladin colocalized with alpha-actinin in stress fibers, focal adhesions, cell-cell junctions, and in embryonic Z lines. The 2 proteins coimmunoprecipitated from fibroblast lysates.The deduced 772-amino acid protein shares about 31% identity over 448 amino acids with chicken connectin-1.