Polysaccharide Biosynthesis Domain Containing Protein 1 (PBDC1)

CXorf26 is found on the plus strand of the short arm of the X chromosome, specifically on the gene locus Xq13.3 spanning the genomic chromosome region from bases 75,393,420-75,397,740. The primary mRNA transcript sequence has 1214 base pairs and its protein product, UPF0368,is composed of 233 amino acids and has a predicted mass of 26,057 Da.[3] The locus where CXorf26 is located, Xq13.3, has known associations to X-linked mental retardation. The third gene located upstream of CXorf26 is ATRX, which encodes for an ATPase/helicase domain, and when mutated causes an X-linked mental retardation syndrome along with alpha thalassemia syndrome; both are known to cause changes in the DNA methylation patterns.