SKI/DACH Domain Containing Protein 1 (SKIDA1)

DLN1 Belongs to the DACH/dachshund family. The Drosophila genes eyeless, eyes absent, sine oculis, and dachshund cooperate as key regulators of retinal cell-fate determination. Homologues of eyeless (Pax6), eyes absent (Eya1-2), and sine oculis (Six3) have been identified and are expressed in the developing vertebrate eye. The structure and expression of mouse Dach, a homologue of Drosophila dachshund. Sequence analysis reveals the presence of two motifs, DD1 and DD2, which may be involved in the function of Dach/Dachshund as gene regulatory factors. In addition, DD1 shares sequence similarity to N-terminal sequences of Ski and SnoN, which are involved in cellular transformation and differentiation. Mouse and human Dach/DACH were localized to chromosome 14E1 and 13q21.3–22, respectively, by fluorescence in situ hybridization.