Solute Carrier Family 22, Member 11 (SLC22A11)

SLC22A11 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.OAT4 also mediated transport of ochratoxin A. OAT4-mediated transport of estrone sulfate was inhibited by several sulfate conjugates. In contrast, glucuronide conjugates showed little or no inhibitory effect on the OAT-mediated transport of estrone sulfate. Cha et al. (2000) demonstrated that OAT4 interacted with chemically heterogeneous anionic compounds, such as nonsteroidal antiinflammatory drugs, diuretics, sulfobromophthalein, penicillin G, and bile salts, whereas it did not interact with tetraethylammonium, an organic cation.