Adrenomedullin Receptor (AMR)

Adrenomedullin is a 52-amino acid peptide involved in vasodilation and body fluid homeostasis. By PCR on human genomic DNA using primers based on the rat ADM receptor (Admr), Hanze et al. (1997) isolated a cDNA encoding human ADMR, which they called AMR. Sequence analysis predicted that the 404-amino acid, 7-transmembrane ADMR protein, which is 73% identical to the rat ADM receptor, contains 2 potential N-terminal N-linked glycosylation sites and several potential ser and thr C-terminal cytoplasmic phosphorylation sites. Northern blot analysis detected highest expression of a major 1.8-kb ADMR transcript in heart, skeletal muscle, liver, pancreas, stomach, spleen, lymph node, bone marrow, adrenal gland, and thyroid, with lower expression in brain, lung, placenta, small intestine, thymus, and leukocytes.