C-Type Lectin Domain Family 1, Member A (CLEC1A)

CLEC1A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.The deduced 280-amino acid type II transmembrane CLEC1 protein has a single carbohydrate recognition domain (CRD) with 6 conserved and 2 additional cysteine residues. Like CD94 and OLR1, the CLEC1 CRD lacks the amino acids necessary for calcium-dependent carbohydrate binding. CLEC1 also possesses a cytoplasmic putative immunoreceptor tyrosine-based motif (YSST) and several potential phosphorylation sites.