C1D Nuclear Receptor Corepressor (C1D)

C1D is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.The full-length cDNA encodes a deduced 141-amino acid protein that shares 89% sequence identity with the mouse protein. Both proteins contain nuclear localization signals but no known DNA-binding motifs. Western blot analysis revealed expression of a 16-kD human protein, as well as a 32-kD band believed to be an SDS-resistant homodimer, in human fibroblasts.