CD2 Binding Protein 2 (CD2BP2)

CD2BP2 encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7.Alternative splicing results in multiple transcript variants but their biological validity has not been determined. The authors noted that a segment near the C terminus contains a consensus site for tyrosine phosphorylation. RNA blot analysis indicated that CD2BP2 is expressed in a wide variety of organs as approximately 1.35- and 4-kb transcripts.