Cell Adhesion Molecule 2 (CADM2)

By searching databases for sequences similar to SYNCAM (IGSF4), Biederer (2006) identified IGSF4D, which he called SYNCAM2. SYNCAM2 contains an N-terminal signal peptide, followed by 3 Ig-like domains of the V-set, C1-set, and I-set subclasses, a transmembrane segment, and an intracellular C terminus with motifs for interaction with protein 4.1 (EPB41) and type II PDZ domains. The third Ig-like domain contains N-glycosylation sites, and alternative splicing introduces potential O-glycosylation sites prior to the transmembrane region. SYNCAM2 shares highest homology with other SYNCAM proteins in the Ig-like domains and the cytosolic protein-protein interaction motifs.the IGSF4D gene contains 10 exons and spans 1.11 Mb. It has 2 alternative first exons, and the first intron is 843 kb long.