Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2)

CCRl2 encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. CCRL2 contains a 7-transmembrane topography and 2 potential N-glycosylation sites. It shares 43.1% amino acid identity with CKR1 and 40.5 to 42.7% identity with several other cytokine receptors. Northern blot analysis detected a 1.7-kb transcript expressed predominantly in spleen, fetal liver, lymph node, bone marrow, lung, and heart. Expression was lower in thymus and placenta, marginal in skeletal muscle, and was not detected in several other tissues.