Chemokine C-X-C-Motif Receptor 6 (CXCR6)

C-X-C chemokine receptor type 6 is a protein encoded by the CXCR6 gene.CXCR6 has also recently been designated CD186 .By expression cloning of mouse Cxcl16, Matloubian et al. (2000) identified a protein with 71% amino acid identity to human BONZO, which they renamed CXCR6.Matloubian et al. (2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp.By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al. (1997) mapped the single-copy STRL33 gene to chromosome 3.