Chemokine C-X3-C-Motif Receptor 1 (CX3CR1)

Only one member belongs to the CX3C sub-family of chemokine receptors - CX3CR1. As the name suggests, this receptor binds the chemokine CX3CL1 (also called neurotactin or fractalkine).Raport et al. (1995) used human-mouse somatic cell hybrids to map the V28 (CX3CR1) gene to 3pter-p21, near CMKBR1. Based on the sequence similarity of V28 to several chemokine receptors, its expression in leukocytes, and its chromosomal location near CMKBR1, Raport et al. (1995) speculated that V28 may be a member of the chemokine receptor (CCR) family. By radiation hybrid analysis and organization of BAC contigs by FISH on combed genomic DNA, Maho et al. (1999) localized the CX3CR1 gene within the CCR cluster at 3p21.3.