Collectin Placenta 1 (CLP1)

COLEC12 contains an N-terminal leucine zipper transmembrane region, a coiled-coil domain, a collagen domain, and a C-terminal C-type lectin/carbohydrate recognition domain. It also has several putative sites for N-glycosylation, a serine/threonine-rich region, and a putative internalization signal.COLEC12 was detected in most vascular endothelial cells in all murine vessels and human heart sections, but it was not detected in macrophages, monocytes, and hepatic Kupffer cells. Immunoblot and flow cytometric analyses indicated that COLEC12 is a membrane glycoprotein of about 140 kD in human umbilical vein or arterial endothelial cells, placenta membrane extracts, and transfected CHO cells. Deglycosylation of in vitro translated COLEC12 resulted in a protein with an apparent molecular mass of 90 kD.