G Protein Coupled Receptor 141 (GPR141)

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) .CloningBack to Top By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR141. Fredriksson et al. (2003) mapped the GPR141 gene to chromosome 7p14.1. They mapped the mouse Gpr141 gene to chromosome 13.The deduced 299-amino acid protein assumes a classic 7-transmembrane (TM) topology. Instead of the DRY motif in the intracellular side of TM3, GPR141 has a TRY motif, and it has no classic NSxxNPxxY motif in TM7. GPR141 shares 67% amino acid identity with mouse Gpr141. EST database analysis indicated that GPR141 is expressed in bone marrow.Fredriksson et al. (2003) determined that the mouse and human GPR141 genes contain a single coding exon.