G Protein Coupled Receptor 15 (GPR15)

Heiber et al. (1996) used sequence similarities among G protein-coupled receptor genes to discover a novel receptor gene. Using primers based on conserved regions of the opioid-related receptors, they isolated a PCR product that was used to locate the full-length coding region of a human receptor gene they named GPR15.A comparison of the amino acid sequence of the receptor encoded by GPR15 with other receptors revealed that it shared sequence identity with the angiotensin II receptors type 1 and type 2, the interleukin 8 b receptor , and the orphan receptors GPR1 and angiotensin receptor-like 1. By fluorescence in situ hybridization, Heiber et al. (1996) mapped GPR15 to 3q11.2-q13.1.