G Protein Coupled Receptor 176 (GPR176)

Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters.By screening a fetal brain cDNA library with rat Gpr176, Hata et al. (1995) cloned full-length human GPR176, which they called HB954. The deduced protein contains 515 amino acids and has a calculated molecular mass of 57.0 kD. GPR176 has 4 N-glycosylation sites near its N terminus, 7 transmembrane domains, and a large C-terminal cytosolic domain. Northern blot analysis of rat tissues showed low expression in brain and spleen, trace expression in kidney, and no expression in heart or testis.