G Protein Coupled Receptor 31 (GPR31)

Zingoni et al. (1997) cloned a novel G protein-coupled receptor (GPCR) from a human placenta cDNA library. They reported that the gene encodes a 319-amino acid polypeptide with 7 predicted transmembrane domains and 25 to 33% homology to other members of the GPCR superfamily.Zingoni et al. (1997) were unable to detect a GPR31 transcript using Northern blotting. By using RT-PCR, they detected a transcript at low levels in several cell lines of varied origins.Zingoni et al. (1997) used fluorescence in situ hybridization to map GPR31 to human chromosome 6q27. They noted that 2 other GPCRs, the MAS protooncogene and the GPRCY4 gene, have also been mapped to this locus.