G Protein Coupled Receptor 32 (GPR32)

G protein-coupled receptors (GPCRs), such as GPR32, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.Marchese et al. (1998) used PCR of human genomic DNA and genomic library screening to isolate a novel gene, termed GPR32. GPR32 encodes a 356-amino acid polypeptide that has greatest similarity to chemoattractant receptors, particularly the formylpeptide receptor (FPR1; 136537). Marchese et al. (1998) also isolated a pseudogene, which is 93% identical to GPR32 at the amino acid level, encoding a 4-bp deletion relative to GPR32.