G Protein Coupled Receptor 62 (GPR62)

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.Lee et al. (2001) identified GPR62 within human genomic DNA using GPR61 as probe. Primers to the intronless sequence were synthesized, and GPR62 cDNA was amplified by PCR and cloned. The deduced 368-amino acid protein shares 44% sequence similarity with GPR61 in the transmembrane domain. Northern blot analysis revealed a single 2.3-kb transcript in all brain regions examined, including basal forebrain, frontal cortex, thalamus, hippocampus, caudate, and putamen. No expression was detected in liver.