G Protein Coupled Receptor 89A (GPR89A)

GPR89A is a nearly identical copy of the GPR89B gene. Hartz (2009) mapped the GPR89A gene to chromosome 1q21.1 based on an alignment of the GPR89A sequence with the genomic sequence and determined that the GPR89A gene is centromeric to the GPR89B gene on chromosome 1q21.1.G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases, and are also the target of approximately 30% of all modern medicinal drugs.