Gamma-Aminobutyric Acid A Receptor Rho 1 (gABRr1)

GABRR1 is a member of a family of ligand-gated chloride channels that are the major inhibitory neurotransmitter receptors in the central nervous system .Cutting et al. (1991) isolated a full-length GABRR1 cDNA, which they called gamma-aminobutyric acid receptor rho-1, from a human retina cDNA library. The cDNA predicted a mature 458-amino acid protein with 30 to 38% sequence similarity to previously identified GABA-A receptors . GABRR1 transcript predominantly in retina, but also in brain, lung, and thymus.compared to other GABA-activated chloride channels expressed singly in oocytes, the rho-1 subunit has a higher sensitivity to picrotoxin, a convulsant inhibitor of GABA-activated chloride channels. Chloride ion substitution experiments confirmed that the rho-1 subunit contains a chloride-selective anion channel.