Gamma-Aminobutyric Acid A Receptor Rho 2 (gABRr2)

GABRR2 is a member of a family of ligand-gated chloride channels that are the major inhibitory neurotransmitter receptors in the central nervous system.One clone contained a single exon from the rho-1 gene, while the second encompassed an exon with 96% identity to the rho-1 gene.Screening of a human retina cDNA library with oligonucleotides specific for the exon in the second clone identified a 3-kb cDNA with an open reading frame of 1,395 bp. The predicted amino acid sequence demonstrated 30 to 38% similarity to alpha, beta, gamma, and delta GABA receptor subunits and 74% similarity to the GABA rho-1 subunit, suggesting that the newly isolated cDNA encodes a new member of the rho subunit family, tentatively named GABA rho-2.