Gamma-Aminobutyric Acid A Receptor Theta (gABRq)

GABRQ is a member of the GABA-A receptor gene family of heteromeric pentameric ligand-gated ion channels through which GABA, the major inhibitory neurotransmitter in the mammalian brain, acts. GABA-A receptors are the site of action of a number of important pharmacologic agents including barbiturates, benzodiazepines, and ethanol.The deduced 627-amino acid GABRQ protein is most similar to the GABA-A receptor beta subunits. GABRQ has a signal peptide; 2 cysteines separated by 13 amino acids; 4 putative transmembrane domains, the third and fourth of which are separated by a large cytoplasmic loop; and 2 potential N-glycosylation sites.