Immunoglobulin Superfamily, Member 16 (IGSF16)

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992).The deduced 224-amino acid type I integral membrane protein contains a 20-residue N-terminal leader sequence, a single V-like Ig extracellular domain, 2 potential N-glycosylation sites, a potentially O-glycosylated hinge-like region, a hydrophobic transmembrane anchor that has a glutamate residue, and a short cytoplasmic tail of 19 amino acids. Northern blot analysis revealed expression of a 1.4-kb transcript in myeloid and B-lymphoid cell lines and in peripheral blood T cells. Expression was weak in other cell lines and undetectable in nonlymphoid tissues.