Integral Membrane Protein 2C (ITM2C)

The integral membrane protein family consists of integral type II membrane glycoproteins with an extracellular C terminus. ITM2C shares several conserved features with other human and murine ITM family members, including 1 N-glycosylation and 2 phosphorylation sites and a single transmembrane domain. Mouse Itm2c shares 92.9% amino acid identity with human ITM2C. ITM2C shares 43.7% amino acid identity with ITM2B, with greatest identity in the C-terminal portion. EST homology searches identified clones encoding a 219-amino acid ITM2C splice variant. The promoter region of ITM2C is GC-rich and contains 3 SP1 and 5 AP-1 binding sites. Northern blot analysis showed strong expression of a 2.1-kb ITM2C transcript in brain and very weak expression in several other tissues.