Interferon Gamma Receptor 2 (IFNgR2)

IFNGR2 encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2.Defects in IFNGR2 are a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.IFNGR2 gene spans over 33 kb of DNA and contains 7 exons. A signal peptide is encoded by exons 1 and 2, the extracellular domain by exons 2, 3, 4, 5, and part of 6. Exon 6 also encodes the entire transmembrane domain and part of the intracellular domain. Exon 7 encodes the remainder of the intracellular domain and contains the 3-prime untranslated region. No TATA or CAAT boxes were found in the promoter region.