Ligand Dependent Nuclear Receptor Interacting Factor 1 (LRIF1)

C1orf103 is a novel nuclear receptor corepressor that associates with the nuclear matrix. Interestingly, both C1orf103 and TP53 have been independently reported to interact with the transcriptional corepressor NOC2L, an inhibitor of histone acetyltransferases exerting a negative control on the transcriptional activity of TP53. This connection establishes a new interaction loop associated with transcriptional regulation. As described above, it was shown that overexpressed PCP4 and TP53 colocalize in COS-1 nuclei in a pattern excluding the nucleoli, which is reminiscent of that seen for NOC2L and TP53.The interactions of PCP4 with TP53, confirmed by colocalization in nucleus and cell periphery of COS-1 cells, and with C1orf103 close one interaction loop associated with transcription and a functional loop associated with calcium signaling.