Nuclear Receptor Binding Factor 2 (NRBF2)

A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor alpha as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast.NRBF2 was originally identified in a yeast two-hybrid screen for factors that interact with the peroxisome proliferator-activated receptor alpha. NRBF2 was also identified in a screen of a keratinocyte cDNA library and named COPR. NRBF2 was proposed to function as a modulator of transcriptional activity that functions to decrease rather than completely repress nuclear-receptor mediated gene expression. Alternative names for NRBF2 include COPR1, COPR2, and NRBF-2.