Olfactory Receptor 10A5 (OR10A5)

Olfactory receptor genes are members of a large multigene family encoding transmembrane signaling proteins required for odorant discrimination. Many of these genes are arranged in large olfactory gene clusters on human chromosomes 6, 11, and 17, as well as distributed on other chromosomes .By screening and PCR amplification of artificial chromosomes and genomic libraries, Buettner et al. (1998) cloned OR10A1, which they designated OR11-403. The deduced protein contains several transmembrane domains.By genomic sequence analysis and FISH, Buettner et al. (1998) mapped the OR10A1 gene to chromosome 11p15, where it resides in a gene cluster with several other olfactory receptor genes.