Pre-B-Lymphocyte Gene 3 (VPREB3)

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.The deduced 123-amino acid human VPREB3 protein shares 67% sequence identity with mouse Vpreb3, 43% identity with a V-lambda segment, and 40% identity with human VPREB. VPREB3 contains a signal peptide, 3 CDR (complementary-determining region) segments, and 3 FR (framework region) segments.