Protocadherin Alpha 10 (PCDHa10)

PCDHA10 is 1 of 15 tandemly arranged genes within the PCDHA gene cluster on chromosome 5q31. The 15 PCDHA genes function as """variable""" exons that are individually spliced to a downstream constant region to form distinct PCDHA transcripts. These transcripts encode cadherin-like cell surface proteins that are expressed in neurons and are present at synaptic junctions. Noonan et al. (2003) identified a 16.7-kb deletion within the PCDHA gene cluster that truncated the PCDHA8 gene and completely removed the PCDHA9 and PCDHA10 genes. This deletion appeared in """normal""" individuals from multiple populations, suggesting that a reduction in protocadherin gene number is not obviously deleterious