Protocadherin Gamma C4 (PCDHgC4)

PCDHGC4 is 1 of 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as """variable""" exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain .Sequence analysis predicted that the 938-amino acid PCDHGC4 protein is 48% identical to PCDHGA3 . The C-terminal 134 amino acids of PCDHGC4 and PCDHGA3 are identical and have a lysine-rich motif. PCDHGC4 has a signal peptide, 2 putative N-linked glycosylation sites, 6 cadherin ectodomains, a transmembrane segment, and a cytoplasmic domain.