Purinergic Receptor P2Y, G Protein Coupled 13 (P2RY13)

P2Y purinoceptor 13 is a protein belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.The deduced 333-amino acid protein lacks a leader peptide but possesses a DRF motif. Northern blot analysis revealed wide expression of a 2.9-kb GPR86 transcript in spleen, with weaker expression in placenta, leukocytes, and brain. In brain, expression was strongest in substantia nigra, thalamus, and medulla.