Purinergic Receptor P2Y, G Protein Coupled 8 (P2RY8)

P2RY8 is a member of the purine nucleotide G protein-coupled receptor gene family and is located in the pseudoautosomal region of the X chromosome .P2RY8 encodes a deduced 359-amino acid protein.P2RY8 is highly expressed in lymphocytes. Weaker expression was seen in heart, kidney, and lung. Granulocytic differentiation was induced by dimethylsulfoxide, and a monocytic/macrophage phenotype was induced by phorbol esters. Moderate P2Y8 expression was detected in undifferentiated cells, and expression was completely downregulated during granulocyte differentiation. P2Y8 transcription decreased until 24 hours of monocytic differentiation, then began to return to higher levels. P2Y8 expression was barely detectable in normal blood leukocytes.