Receptor Accessory Protein 5 (REEP5)

Through study of submicroscopic deletions in 2 unrelated patients with familial adenomatous polyposis coli (FAP), Joslyn et al. (1991) found 3 genes in a 100-kb deleted segment on chromosome 5. MCC, a previous candidate gene, was shown to be located outside the deleted region. One of the new genes contained a sequence identical to SRP19. The second gene, provisionally designated DP1, was transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, which was transcribed in the same orientation as SRP19. In situ hybridization of mouse olfactory epithelium revealed that, unlike Reep1, Reep5 was not expressed in olfactory neurons.