Roundabout, Axon Guidance Receptor, Homolog 2 (ROBO2)

ROBO2 belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. The deduced 1,380-amino acid protein shares 56% identity with ROBO1. RT-PCR ELISA detected highest expression of ROBO2 in adult and fetal brain, adult ovary, and in most individual brain regions examined. Intermediate expression was detected in fetal liver and in adult lung, kidney, spleen, testis, and spinal cord. Little to no expression was detected in adult pancreas, heart, liver, and skeletal muscle.