SH3 And Cysteine Rich Domain Protein (STAC)

RLGS-M is a method for scanning the methylation status of large sections of a genome. Using RLGS-M to scan mouse brain genomic DNA from various developmental stages, Suzuki et al. (1996) found a tissue-specific gel spot whose intensity changed developmentally. STAC corresponding to this spot, which they termed Stac (for Src homology 3 and cysteine-rich domains), encodes a predicted 403-amino acid protein. The mouse Stac gene was used to clone human STAC from a fetal brain cDNA library. The predicted 402-amino acid STAC protein is 83% identical to that of mouse. Suzuki et al. (1996) noted that cysteine-rich and SH3 domains are frequently found in signal transduction proteins, and suggested that STAC may play a role in the neuron-specific signal transduction pathway.