Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15)

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. Siglec-15 is expressed on macrophages and/or dendritic cells of human spleen and lymph nodes.Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule. Siglec-15 is the second human Siglec identified to have an activating signaling potential; unlike Siglec-14, however, it does not have an inhibitory counterpart. Orthologs of Siglec-15 are present not only in mammals but also in other branches of vertebrates; in contrast, no other known Siglec expressed in the immune system has been conserved throughout vertebrate evolution. Siglec-15 probably plays a conserved, regulatory role in the immune system of vertebrates.