Thyroid Hormone Receptor Associated Protein 3 (THRAP3)

For background information on thyroid hormone receptor-associated proteins (TRAPs), Using a HeLa cell line, Ito et al. (1999) cloned TRAP150, the gene encoding the 150-kD subunit of the TRAP complex.The TRAP150 cDNA encodes a 955-amino acid protein with no obvious known sequence motifs. Sequence comparisons revealed a gene of unknown function, designated KIAA0164 by Nagase et al. (1996), that encodes a related human protein (overall identity of 40% and similarity of 55%), thus indicating a putative gene family. Northern blot analysis of multiple human tissues showed that the TRAP150 gene is ubiquitously expressed as an approximately 5.0-kb transcript.