Trace Amine Associated Receptor 2 (TAAR2)

The deduced 306-amino acid human GPR58 protein shares 42% identity with the putative neurotransmitter receptor PNR (TAAR5) and 34% identity with the serotonin receptor 5-HT4 (HTR4). GPR58 shares highest identity with HNHCI32, or GPR57, a human hippocampus cDNA from the patent literature; however, genomic library screening showed that GPR57 represents a pseudogene. GPR58 contains 7 predicted transmembrane domains, potential PKC phosphorylation sites, and residues corresponding to those in biogenic amine-binding receptors that are important for ligand binding. Northern blot analysis did not detect GPR58 expression in human pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain, or liver.