Trace Amine Associated Receptor 6 (TAAR6)

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be """false transmitters""" that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.Quantitative RT-PCR revealed that TRAR4 has comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala, and hippocampus, with the highest expression in hippocampus and the lowest expression in basal ganglia. These results were consistent with a previous expression study that included TRAR4.